Coupled with the Totem of Weakness, Drain Life can heal Lucrezia by 210 points, making it nearly life-saving. The damage buff of Dante can add up to 315 health, nearly her entire life bar. (Not so on Steam because his Beacon of Light does not affect secondary heroes.)
To take full advantage of her Cloak, it is highly effective to make Vampiresa closely compacted together using heroes and allies, and move Lucrezia to the middle of them in Bat form.
Keep her away from Vasile, as his Bloodsucking attack will most likely kill her, preventing her from dealing any damage to him and most likely give him more health. She is best left to deal with his vampire army in the same fashion as mentioned before.
Beware of Lucrezia dying on waves with Vampiresa, as she is vital to killing them effectively.
Lucrezia can instantly kill Ghosts, even in veteran difficulty, because Ghosts have too little health to survive the Cloak. It's best to save the Cloak attack for Vampiresa, because they appear a lot in further waves.
Her name may come from Lucrezia Borgia (1480-1519), a femme fatale who in some circles of folk stories and mythology, was believed to be a vampire.
"The blood is the life."
A line spoken by Dracula, in the 1992 film of the same name, based on the 1897 book by Bram Stoker. The full quote is "The blood is the life... and it shall be mine."
"Blah blah vampire emergency blah"
A word for word line spoken by the character Pam De Beaufort in the HBO series True Blood.
A take on the advertising phrase "Got Milk?" which encourages the drinking of cow milk.
Using this skill creates an aura around Lucrezia in the shape of a red cross. This could be a reference to the humanitarian organization known as the "International Federation of Red Cross and Red Crescent Societies", which provides aid to disaster victims.